A)Puckering in Breast Cancer B)Peau d' orange appearance

  What is the reason for puckering or skin retraction in Breast Cancer?

 1) Desmoplastic Response of tumor leading to shortening of cooper's ligaments
 2) Drainage of lymph fluid from the skin is disrupted
 3) Direct migration of tumor cells
 4) Satellite growth leading to retraction

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5/26/2016 12:19:00 AM

Ref: Schwartzs 10th ed (http://amzn.to/1q10JSc)

Image Source: Wikipedia

   

• Calcifications associated with LCIS typically occur in adjacent tissues. This neighbourhood calcification is a feature that is unique to LCIS and contributes to its diagnosis.
• The average age at diagnosis is 45 years, which is approximately 15 to 25 years younger than the age at diagnosis for invasive breast cancer
• Invasive breast cancer develops in 25% to 35% of women with LCIS. 
• Invasive cancer may develop in either breast, regardless of which breast harbored the initial focus of LCIS, and is detected synchronously with LCIS in 5% of cases. 
• In women with a history of LCIS, up to 65% of subsequent invasive cancers are ductal, not lobular, in origin. 
• For these reasons, LCIS is regarded as a marker of increased risk for invasive breast cancer rather than as an anatomic precursor

5/06/2016 10:42:00 PM